finding may lead to identifying the defects in a variety of others unexplained disorders. 98 By the end of the 19th century, research and reports on HD had been published in many countries and the disease was recognized as a worldwide condition. Effects on Society By finding possible drugs to weaken the binding of the HAP-1 protein, researchers can provide society an incredibly sophisticated, but quick and easy wasy to screen for new treatments.
This paper reflects the research and thoughts of a student at the time the paper was written for a course at Bryn Mawr College. Huntington s, disease - An Overview. Huntington s disease is a hereditary brain disorder that is progressive in neurodegeneration; which means, there is a loss of function and structures of one s neurons. Huntington s disease research news.
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Gene silencing experiments in mouse models have shown that when the expression of mHTT is reduced, symptoms improve. 24 It is thought that the disease is not caused by inadequate production of HTT, but by an increase in the toxic function of mHTT in the body. The study presented evidence that HD patients have much higher mtDNA deletionlevels than agematched controls in the frontal and temporal lobes of the cortex. "Gene suppression strategies for dominantly inherited neurodegenerative diseases: lessons from Huntington's disease and spinocerebellar ataxia". Brody IA, Wilkins RH (1967).